TEDE Communidade: Pró Reitoria de Pesquisa e Pós-Graduação

Prevalência de sequelas pós-Covid-19 no aparelho locomotor de profissionais de saúde: revisão sistemática da literatura

Thu, 28 Aug 2025 00:00:00 GMT

Título: Prevalência de sequelas pós-Covid-19 no aparelho locomotor de profissionais de saúde: revisão sistemática da literatura Autor: Pontes, Marco Antonio Souza Primeiro orientador: Nakagaki, Wilson Romero Abstract: Introduction: Healthcare professionals were highly exposed to COVID-19 infection and vaccine administration during the pandemic. In addition to known systemic effects, musculoskeletal complaints such as myalgia, fatigue, joint pain, and stiffness have been reported, possibly associated with both infection and post-vaccination responses. These conditions may compromise functional capacity and quality of life in this population. Objective: To investigate the prevalence, affected tissues, most common body regions, and motor dysfunctions associated with musculoskeletal sequelae in healthcare professionals with COVID-19 or adverse effects following vaccination. Methods: A systematic review was conducted in PubMed, Embase, and Web of Science databases. Cross-sectional studies evaluating healthcare professionals with confirmed COVID-19 and musculoskeletal sequelae were included. Two independent reviewers performed study selection using Rayyan software. Data extraction was conducted using a standardized form, and methodological quality was assessed with the adapted Newcastle-Ottawa Scale. Due to methodological heterogeneity, a meta-analysis was not feasible; results were summarized narratively. Results: Five studies published between 2021 and 2023 were included, comprising 2,979 participants, mostly women (n = 1,963). Studies were conducted in countries including the Netherlands, United States, Ethiopia, Sweden, and Nepal. The most reported symptoms were myalgia, joint stiffness, spasms, and localized pain, mainly in the neck, back, and shoulders. Pain intensity ranged from mild to moderate (3–4 on the visual analog scale). Three studies assessed musculoskeletal adverse effects following vaccination, identifying local pain, functional limitation, and cases of subacromial bursitis and biceps tendinitis confirmed by ultrasound. Symptoms lasted from 4 hours to 7 days. The included studies were classified as having moderate methodological quality. Conclusion: Healthcare professionals may experience persistent musculoskeletal symptoms following COVID-19 infection or vaccination, with varying functional impact. Despite methodological limitations and lack of data on long-term disability, the findings highlight the importance of clinical and functional monitoring of healthcare workers in the post-pandemic period. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação

A influência da infecção viral em mulheres grávidas na patologia do transtorno do espectro autista: uma revisão sistemática com metanálise

Tue, 31 Mar 2026 00:00:00 GMT

Título: A influência da infecção viral em mulheres grávidas na patologia do transtorno do espectro autista: uma revisão sistemática com metanálise Autor: Mantovani, Priscila Vieira de Lucena Primeiro orientador: Keller, Rogéria Abstract: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication, restricted interests, and repetitive behaviors. Infection is a common environmental factor that can influence the development of ASD and, when caused by viruses, is highly prevalent in all age groups, including the intrauterine period. The etiology of ASD has been the subject of intense research, but there are gaps to be filled. Objective: To analyze the interaction between viral infection during pregnancy and ASD. Methods: A systematic review with meta-analysis was conducted to answer the following question: What is the influence of viral infection in pregnant women on the development of Autism Spectrum Disorder? Articles were from the period of 1979 until 2023. The articles were observational, retrospective, prospective, case-control, and cohort studies that described the clinical outcome of children whose mothers were exposed to infections during pregnancy, focusing on the development or not of psychological disorders. The methodology used followed PRISMA, and Review Manager 5.4 software was used for meta-analysis calculations. Results: A total of 32 studies were included, and after analysis, the combined result yielded an OR of 0.29, demonstrating that viral infection during pregnancy increased the probability of ASD in offspring by 71%, a statistically significant result, since the confidence interval does not cross the value 1. Conclusion: In fact, this systematic review with meta-analysis found an increased risk of ASD in cases of maternal infection during pregnancy. These results may be useful for the preparation and development of prophylactic measures against ASD, as we may be close to discovering its etiology. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação

Impacto da pandemia por COVID-19 no perfil de pacientes da unidade de terapia intensiva coronariana de um hospital público terciário

Thu, 25 Jul 2024 00:00:00 GMT

Título: Impacto da pandemia por COVID-19 no perfil de pacientes da unidade de terapia intensiva coronariana de um hospital público terciário Autor: Bosso, Carlos Eduardo da Costa Nunes Primeiro orientador: Carneiro, Luiz Euribel Prestes Abstract: Introduction: The COVID-19 pandemic, which began in 2019, has overwhelmed healthcare systems globally, significantly impacting Intensive Care Units (ICUs), including Coronary Care Units (CCUs). This study analyzes the impact of the pandemic on the patient profile and performance of the CCU at the Regional Hospital of Presidente Prudente (HR), a tertiary public hospital of reference in the western region of São Paulo state. Objectives: To analyze the profile of patients admitted to the HR CCU before, during, and after the COVID-19 pandemic, evaluating changes concerning severity, unit performance indicators, and clinical outcomes. Materials and Methods: This is a retrospective observational study using data from patients admitted to the HR CCU between June 2019 and December 2023. The study was divided into three periods: pre-pandemic (June 2019 to June 2020), pandemic (July 2020 to December 2022), and post-pandemic (January 2023 to December 2023). Demographic, clinical, and unit performance indicator data, such as occupancy rate, average length of stay, bed turnover, and mortality, were collected. Binary logistic regression was performed to assess mortality in each period. Results: A cohort of 3,657 patients was assessed, comprising 919 in the pre-pandemic group, 1,884 in the pandemic group, and 854 in the post-pandemic group. During the pandemic, there was a reduction in the average monthly admissions to the CCU, with pre-pandemic admissions averaging 70.7, pandemic admissions at 62.8, and post-pandemic admissions at 71.2. There was a notable decrease in admissions due to cardiovascular reasons (86.2% pre-pandemic versus 73.6% during the pandemic, p<0.05). Additionally, an increase in the severity of admitted patients was observed, as indicated by the SAPS 3 score (pre-pandemic 44.2, pandemic 48.3, and post-pandemic 45.9; p=0.001). The mortality rate remained consistent throughout the pandemic period. Logistic regression analysis revealed higher mortality rates in the CCU among older patients (OR 1.03; 95% CI: 1.02-1.04), females (OR 1.40; 95% CI: 1.08-1.82), those requiring assistance for daily activities, and those who were bedridden (OR 1.50; 95% CI: 1.08-2.08 and OR 2.69; 95% CI: 1.70-4.25, respectively), as well as patients without a prior acute myocardial infarction (AMI) (OR 1.86; 95% CI: 1.25-2.78). Conclusion: We concluded that the COVID-19 pandemic altered the profile of the CCU. A decrease in cardiovascular admissions was observed during the pandemic period, along with an increase in all-cause hospital mortality among patients post-discharge from the CCU during and after the pandemic. However, there was no observed increase in mortality within the CCU itself. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação

Impactos da exposição prolongada a uma mistura ambientalmente relevante de desreguladores endócrinos no testículo de ratos

Fri, 05 Dec 2025 00:00:00 GMT

Título: Impactos da exposição prolongada a uma mistura ambientalmente relevante de desreguladores endócrinos no testículo de ratos Autor: Silveira, Raissa Souza Lima Bruno Primeiro orientador: Mendes, Leonardo de Oliveira Abstract: Endocrine disruptors (EDs) are environmental contaminants commonly found in personal care products, food preservatives, domestic and agricultural pesticides, construction materials, plastics, and cleaning products. These compounds interfere with hormone dependent organs such as the testes, negatively affecting male fertility. This study aimed to evaluate testicular histoarchitecture in rats chronically exposed to an environmentally relevant mixture of EDs from gestation through adulthood. Pregnant Sprague Dawley rats were randomly assigned to two groups: Control (corn oil, 2 mL/kg) and ED Mix (32.11 mg/kg/day of a mixture of 12 compounds, including phthalates, pesticides, UV filters, bisphenol A, and butylparaben, in corn oil, 2 mL/kg). Dosing by oral gavage occurred from gestational day 7 (GD7) to postnatal day 21 (PND21). After weaning (PND22), male offspring (F1 generation) continued to receive the ED mixture until PND220. Testes were collected, fixed in Metacarn, and processed for histological analysis. Sections were stained with hematoxylin eosin and picrosirius red for morphometric assessment and collagen quantification. Chronic exposure to the ED mixture significantly reduced seminiferous tubule diameter and germinal epithelium height, and decreased the number of Sertoli and Leydig cells compared to control animals. Notably, the proportion of seminiferous tubules in early spermatogenic stages (I–VI) increased from 53.17 ± 1.98 in controls to 61.00 ± 0.87 in the exposed group (p = 0.002), while stages VII–VIII decreased from 46.5 [38.25–48.0] to 37.0 [33.0–39.0] (p = 0.017), indicating delayed spermatogenic progression. The incidence of abnormal tubules also increased significantly (from 0 [0–1] to 2 [1–3], p = 0.002), characterized primarily by vacuolization and the presence of immature germ cells. In contrast, no significant difference was observed in relative interstitial collagen volume between groups (p = 0.0603). These findings demonstrate that chronic ED exposure from prenatal life through adulthood induces substantial structural and functional alterations in the testis, consistent with evidence showing that endocrine active compounds disrupt steroidogenesis and spermatogenesis in male reproductive systems. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação