http://bdtd.unoeste.br:8080/jspui/handle/tede/481 Mestrado em Meio Ambiente e Desenvolvimento Regional Wed, 21 Oct 2026 20:11:36 GMT 2026-10-21T20:11:36Z http://bdtd.unoeste.br:8080/jspui/handle/jspui/1795 Título: Avaliação in sílico do perfil de expressão genica dos tipos e subtipos de câncer de mama Autor: OLIVEIRA, Victor Hugo Garcia de Primeiro orientador: MARECO, Edson Assunção Abstract: Breast cancer is the most common neoplasm among women in Brazil, with notable incidence and mortality rates in the South and Southeast regions. The triple-negative subtype (TNBC) is one of the most aggressive and difficult to treat due to the absence of hormone receptors. This study aims to identify gene co-expression modules associated with TNBC using the Weighted Gene Co-Expression Network Analysis (WGCNA) methodology, based on publicly available data from The Cancer Genome Atlas (TCGA-BRCA). The research was conducted with a quantitative and exploratory approach, utilizing bioinformatics analysis of transcriptomes from 1,032 tumor samples, including 115 TNBC cases and 917 hormonal subtypes. The applied methods involved data filtering and normalization using the DESeq2 package, differential gene expression analysis, and gene co-expression network identification. A total of 21 co-expression modules were identified, with two standing out: "MEblack", associated with hormonal subtypes, and "MEcyan", correlated with TNBC. Functional enrichment analysis revealed that the MEblack module is related to hormonal signaling and glandular development, whereas the MEcyan module is associated with cellular organization and proliferation. Protein-protein interaction (PPI) networks identified key genes involved in tumorigenesis, such as ESR1, ERBB4, PGR, and GATA3, which play a critical role in cell growth regulation and tissue differentiation. This study highlights the importance of gene network analysis in understanding the molecular differences between hormonal and non-hormonal breast cancer subtypes, providing insights into novel biomarkers and therapeutic targets. The application of bioinformatics approaches advances the development of personalized diagnostic and treatment strategies for TNBC, while also contributing to public health policies focused on oncology. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação Fri, 31 Jan 2025 00:00:00 GMT http://bdtd.unoeste.br:8080/jspui/handle/jspui/1795 2025-01-31T00:00:00Z http://bdtd.unoeste.br:8080/jspui/handle/jspui/1785 Título: Diagnóstico ambiental e adaptação de Protocolo de Avaliação Rápida no Córrego do Limoeiro Autor: LOPES, Matilde Barga dos Santos Primeiro orientador: Uliana, Maíra Rodrigues Abstract: The growing demand of the population, coupled with the pollution of watercourses, results in a reduction in the amounts of freshwater available for human consumption, requiring prompt actions to mitigate impacts and slow down degradation. Understanding the responses of rivers to anthropogenic changes is essential for water resource management and requires a holistic perspective. According to the United Nations (UN), if water management is not implemented, 75% of the world's population will experience water scarcity by 2050. In this context, the Rapid River Assessment Protocol (PAR) was developed as a method for evaluating river ecosystems. This protocol is based on visual criteria and allows adaptation to the specific characteristics of the observed landscape. The research aims to contribute scientific knowledge by investigating the various PARs applied by students from elementary school to higher education in Brazil, addressing the cross-cutting nature of environmental education within the academic context, and proposed the adaptation of a PAR that would be accessible to all academic levels in Presidente Prudente. The study was based on three reference protocols, which were adapted and applied by elementary, high school, and university students according to the peculiarities of their respective Brazilian study regions over the past three decades. According to the phenomenological methodology, five observed points were evaluated, resulting in the selection of qualitative parameters for composing the adapted instrument, following reference protocols, including: indicators of erosion; anthropogenic alterations; presence of aquatic plants; odor; color and oiliness of the water; presence of solid waste and domestic sewage; type of bank occupation. According to the phenomenological methodology, five observed points were evaluated, resulting in the selection of (qualitative) parameters for the composition of the adapted instrument, following reference protocols, including indicators of erosion; anthropogenic alterations; presence of aquatic plants; odor; color and oiliness of the water; presence of solid waste and domestic sewage; type of bank occupation; and presence of riparian vegetation. Thus, the adapted PAR is proposed as an accessible and low-cost solution to be used by schools and universities to promote environmental education and student empowerment in integration with the subjects taught by teachers in watercourses near the institutions. The results of the application of the adapted PAR demonstrated that the most impacted section of the Limoeiro Stream is the source (Point 1), which shows severe impacts due to real estate expansion in the region. The environmental condition of the Limoeiro Stream presented a disturbance level in 40% of the total points evaluated, with Point 1 being the most affected, and changes were observed at Points 4 and 5 due to parameters such as color and odor influenced by the discharge of effluents and waste disposal. The result of applying the adapted PAR provides Watershed Committees with a simplified environmental diagnosis, allowing for the direction of actions toward the impacted sections. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação Fri, 28 Nov 2025 00:00:00 GMT http://bdtd.unoeste.br:8080/jspui/handle/jspui/1785 2025-11-28T00:00:00Z http://bdtd.unoeste.br:8080/jspui/handle/jspui/1752 Título: Nova argamassa constituída por resíduos de rocha magmática e nanopartículas de óxido de zinco para ação antimicrobiana e fotocatalítica Autor: SHIMADA, Pollyana Saori Primeiro orientador: Kinoshita , Angela Mitie Otta Abstract: The application of nanotechnology in the construction sector has enabled the incorporation of new properties into traditional materials in an efficient and innovative manner. Among these features is photocatalysis, which imparts self-cleaning and antimicrobial properties to materials, making them fundamental for reducing pollutants present in liquid effluents and representing an interesting alternative to the emerging environmental crisis—water pollution. In this specific context, the research focuses on developing a photocatalytic mortar using powdered magmatic rock (gray andorinha granite) as a partial substitute for natural sand. This residue acts as a precursor to photocatalytic properties, containing titanium dioxide and iron oxide, which have the potential to facilitate photocatalysis. Test specimens were produced with partial substitutions of natural sand by crushed residue in proportions of 15%, 30%, and 30% combined with the addition of ZnO-NP nanoparticles (0.33%) to intensify photocatalytic activity. A control sample was prepared without the addition of residue or ZnO-NP. The photocatalytic efficiency of the developed mortars was tested by degrading methylene blue in mortar plates immersed in an aqueous solution and exposed to sunlight for four hours. The results showed that samples containing the residue exhibited superior photocatalytic performance compared to the control, demonstrating the efficacy of the residue in dye degradation. The sample RR-30/NP-1 showed one of the best photocatalytic performances, with efficiency surpassing that of the control (81.37%), degrading 88.68% of the methylene blue dye. Additionally, the use of powdered magmatic rock significantly increased the compressive strength of the mortar. After 56 days of curing, the RR-15, RR-30, and RR-30/NP-1 samples exceeded the reference samples, whose strengths were: 76.61 MPa for the control, 88.22 MPa for the RR-15 sample, 80.59 MPa for the RR-30 sample, and 102.15 MPa for the RR-30/NP-1 sample, highlighting their superiority over the control. Therefore, the developed material exhibits characteristics that promote sustainability by providing environmental advantages through its application in effluent treatment and the reuse of industrial residues, reducing the extraction of natural resources. In this way, this work aligns with three objectives outlined in the United Nations' 2030 Agenda: “Industry, Innovation, and Infrastructure,” “Responsible Consumption and Production,” and “Clean Water and Sanitation.” Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação Wed, 14 May 2025 00:00:00 GMT http://bdtd.unoeste.br:8080/jspui/handle/jspui/1752 2025-05-14T00:00:00Z http://bdtd.unoeste.br:8080/jspui/handle/jspui/1743 Título: Avaliação do impacto socioeconômico da cultura do Baru em municípios com comunidades em situação vulnerável Autor: Reis, Jucimar Alves dos Primeiro orientador: Osco , Lucas Prado Abstract: Baru (Dipteryx alata), a native species of the Brazilian cerrado, has emerged as a significant economic alternative for low-income communities in the northwest region of Minas Gerais. Despite structural and market challenges, the extractivism of baru has adopted sustainable practices that contribute to the preservation of the cerrado's biodiversity while providing an essential source of income for small farmers and local extractivists. This study aims to assess the socioeconomic impact of this activity in low-income municipalities of the northwest mesoregion of Minas Gerais, focusing on its relevance to family farming and regional development. The research provides a detailed analysis of extractivism practices, commercialization, and sustainable management, combining socioeconomic and environmental data obtained through documentary research, interviews, and geospatial analysis. The findings reveal the potential of baru extractivism to boost the local economy sustainably while proposing measures to optimize existing practices, minimize environmental impacts, and expand the benefits for the involved communities. The recommendations aim to strengthen cooperatives, add value to baru-derived products, and expand commercialization networks. Instituição: Universidade do Oeste Paulista Tipo do documento: Dissertação Thu, 03 Oct 2024 00:00:00 GMT http://bdtd.unoeste.br:8080/jspui/handle/jspui/1743 2024-10-03T00:00:00Z