Treinamento intervalado de alta intensidade é associado a divergentes adaptações da expressão genica no músculo esquelético em modelo de rato de hipertensão.

Abstract

Hypertension and aging cause endothelial muscular alterations that can compromise the exercise capacity. There is evidence that the high-intensity interval training (HIIT) can also be prescribed for hypertensives. However, there are no studies that assess in a comparative way this type of exercise in the gene expression of endothelial markers in the skeletal muscles with distinct functions in aging rats. 26 specimens of 12-month-old male rats were used, divided in three different groups: spontaneously hypertensive sedentary control, spontaneously hypertensive trained and Wistar Kyoto sedentary control. The training protocol was carried out on a treadmill adapted to rodents, 50 minutes/day, 5 days/week totalizing 8 weeks. The gene expression was determined by the real-time PCR technique. There was a divergent adaptive response in the aging hypertensive rats subjected to HIIT, showing a positive influence in the angiogenic pattern with worsening of vasodilator activity in the soleus muscle and without alteration in the diaphragm muscle.