Comparação dos processos patológicos gerais no epitélio pulmonar de ratos espontaneamente hipertensos submetidos ao treinamento intervalado de alta intensidade

Abstract

Introduction: Hypertension is often associated with metabolic disorders and can be aggravated by other factors, when not properly treated it can lead to serious problems; which can culminate in events of death or disability. The issue appears as a subject that generates burdens on quality of life and health coffers. Inexpensive measures and easy adherence to the population, such as high-intensity interval training (HIIT) are powerful weapons in helping health teams to combat hypertension. High-intensity aerobic exercises are interspersed with recovery periods for a short period of time. In the study we used animals that present a hypertension picture similar to that of humans, therefore with the objective of analyzing the airway in its pulmonary vasculature and parenchyma by microscopy. Methodology: 16 Wistar Kyoto rats were divided into spontaneously hypertensive with sedentary control (SHR, n = 8), spontaneously trained hypertensive (SHR + T, n = 8). The animals went through adaptation processes on a treadmill for 5 minutes for 5 days. Each session performed consisted of 3 phases: warm-up, HIIT and deceleration. Results: the HIIT used in hypertensive individuals, does not appear to cause epithelial damage. There was no significance in the data obtained when observing the pulmonary epithelia of hypertensive animals exposed to training and not exposed. The results presented prove that the training method studied is safe for the pulmonary epithelium. Conclusions: The HIIT training can be used safely, when talking about pulmonary epithelial tissue, the animals in the study did not show significant changes to contraindicate it.