Detomidina isolada e associada à morfina e à metadona para abordagem da cavidade oral em equinos: efeitos sedativos, antinociceptivos e cardiorrespiratórios

Abstract

This study aimed to evaluate the sedative, antinociceptive and cardiopulmonary effects of detomidine alone and in combination with morphine or methadone to the oral cavity approach. Six adult mares were evaluated using a crossover design with at least 7 days between treatments. All the horses were medicated with detomidine (20µg/kg, IV), detomidine (10µg/kg, IV) in combination with morphine (0,1mg/kg, IV) or methadone (0,1mg/kg, IV). Behaviors alteration, sedation degree, oral cavity sensibility, muscle tone of tongue, heart rate, mean arterial blood pressure, arterial blood gases were investigated during 120 minutes. The parametric data were analyzed with ANOVA and Tukey s test, and non parametric data were analyzed with Kruskall-Wallis and Fridman s test with post-Dunn test (P<0,05). In all the treatment groups, the maximum sedative effect was observed between 5 and 60 minutes after drugs administration. The must sedative effect was observed in detomidine horses treated. Respiratory stability was observed in all the groups, with more pronounced cardiovascular changes in DET group. It was concluded that all treatments were satisfactory for oral cavity approach. However, the combination of opioids did not potentiate the sedative effect and, neither increased or prolonged the antinoceptive effect mediate by detomidine.