Efeito da administração de hormônio do crescimento (GH) com e sem atividade física na bioquímica sérica, no peso corporal, e no peso dos órgãos de ratas Wistar

Abstract

The goal of this project was to verify the effect of the administration of GH associated or not associated to physical activity in the serum biochemistry, body weight and in the weight of Wistar rats organs. In the present research, 40 rats were used, 9 years old, divided in four groups (n=10): CT (control group without physical activity and without administration of GH), GH (group without physical activity and with administration of GH), Ex (group with physical activity and without administration of GH), ExGH (group with physical activity and administration of GH). After 30 days, the serum biochemistry, the animals weight, organs weight, length and abdominal circumference were measured. The variables were submitted to the analysis of variance (ANOVA), followed by the Tukey test. There was no statistical difference in the gain of weight and in the growth of the animals among the different groups. There was a greater gain of abdominal circumference in the ExGH group compared to the GH group, but there was no difference in the retro abdominal fat weight. Renal weight was only different in the GH group, it was greater than Ex and ExGH (p<0.05). Regarding serum biochemistry, the ExGH group presented lower urea rates than the other groups (p<0.05), and the Ex group presented a higher dosage of alkaline phosphatase, statistically differing from the other groups. In conclusion, the use of GH in the 0.2 UI/Kg dosage per month associated or not to the practice of physical activity doesn t alter the body weight or the overall length of the female animals. The use of GH not associated to physical activity leads to an increase of the renal weight. The use of GH combined with physical activity decreases the serum urea, without altering creatinine. Physical activity without the administration of GH increases the alkaline phosphatase.