Lesões renais em ratos Wistar intoxicados experimentalmente com veneno da Caudisona durissa terrifica em diferentes doses

Abstract

Snakebites with Caudisona durissa terrifica are of great importance for the high mortality rate in humans and animals. Neurotoxicity, myotoxicity, abnormal coagulation, hepato and nephrotoxicity are the most commonly observed clinical signs. The present study aimed to evaluate by histopathology the kidney of Wistar rats experimentally intoxicated crotalic venom at different doses. Ninety rats were divided into three groups as follows: control group (CG) - received solution of sodium chloride 0.9% intramuscular (IM); Group 4 (G4) - received 4mg/kg of crotalic venom IM; Group 8 (G8) -received 8mg/kg of crotalic venom IM. Histopathological examination of the kidney was performed in 6 hours time (M6) and 24 hours (M24) after the inoculation of the venom (AV). Moderate renal congestion was observed in both groups, hydropic degeneration and acute tubular necrosis little to G4 in M6 and high incidence of acute tubular necrosis in M24, however, acute tubular necrosis was predominant in the G8 at both times. It is concluded that in Wistar rats using doses of 4 and 8mg/Kg after 24 hours intoxication, crotalic venom causes histological changes in the kidney characterized by congestion, hydropic degeneration and acute tubular necrosis, and the signal strength dose dependent. Further studies are needed to evaluate the causes that lead to the installation of histological renal changes in this species.