Hormônio do Crescimento (GH) e Atividade Física no Metabolismo de Ratos Wistar Machos

Abstract

The growth hormone (GH) is the hormone secreted by the anterior hypophysis. It is necessary for the longitudinal growth and for certain aspects of the global metabolism, promoting the growth and expansion of all body tissues until their maturation. The goal of this project was to verify the effect of the administration of GH associated or not associated to physical activity in the serum biochemistry, body weight and in the weight of Wistar rats organs. In the present research, 40 rats were used, divided in four groups (n=10): CT (group without physical activity and without administration of GH), GH (group without physical activity and with administration of GH), Ex (group with physical activity and without administration of GH), and ExGH (group with physical activity and with administration of GH). The rats that received 0.2 IU/Kg of GH subcutaneous, they received this hormone each two days for 30 days (Monday, Wednesday and Friday). The other rats from groups without treatment with GH received the same volume of saline solution. After 30 days, the serum biochemistry, the weight of animals, the organs weight, and the length and abdominal circumference were measured. The data were submitted to the analysis of variance (ANOVA), followed by the Tukey test (p<0.05). It was observed a significant decrease in the weight of retroabdominal fat in the group of animals with hormone and physical activity.