Análise morfológica e morfometrica de útero, ovário, glândulas Adrenais e perfil lipídico de ratas suplementadas com capsiate

Abstract

Obesity is characterized by excessive accumulation of adipose tissue, of multifactorial origin. In pursuit of weight reduction, individuals use functional foods, for example the Capsiate, CH-19 extract sweet (Capsicum annuum L.), which contains capsinoids, it is a capsaicin analog, not pungent, with thermogenic properties. The capsiate exhibits potent activity against angiogenesis and vascular permeability induced by vascular endothelial growth factor. The study was conducted face lack studies on capsianóides in reproductive organs in the literature. The aim: was to evaluate the effect of capsiate on the histology of the uterus, ovary, adrenal gland and lipid profile of obese and non-obese rats. Material and methods: Sixty-four male Wistar rats were divided into four groups (n = 16): Control; Obese; Capsiate and Capsiate Obeso. Groups Control and Capsiate received commercial feed. Group Obese and Capsiate Obese received palatable high fat die. For groups Capsiate and Capsiate Obese it was administered by gavage 10 mg capsiate diluted in 0.5 ml of filtered water, 1 once day, for groups Control and Obese it was administered by gavage 0,5 ml of filtered water (placebo). After 12 weeks, the animals anesthetized, blood collected and euthanized. Reproductive organs and the adrenal glands they were stained with HE technique and submitted to morphological analysis and morphometric. Statistical analysis, it was verified by the Levene test, was employed (one-way ANOVA), contrasts with the Tukey method. Performed using SPSS 16.0 software and 5% significance level. Results: significant elevation in HDL Col in the groups Capsiate and Capsiate Obese. The thickness of the endometrium was lower (p <0.05) in Capsiate and was observed increase (p <0.05) in the number of secondary follicles and corpus luteum in group Capsiate Obese. The glomerular regions, crosslinked and medullary they had a lower thickness (p <0.05) in Capsiate group compared to the control. Conclusion: The capsiate reduces endometrial proliferation no obese rats, increases the number of corpus luteum in obese rats and induces an increase in HDL-cholesterol, but not prevented increase in body weight of rats. However, further studies are needed to evaluate the effect of capsiate in reproductive organs because of the shortage in the scientific literature.