Efeito de Mananoligossacarídeos sobre parâmetros densitométricos e biomecânicos de ratos em crescimento

Abstract

The objective of this study is to evaluate the effect of manann oligosaccharides (MOS) prebiotics on densitometry parameters of the femur by means of bone densitometry and biomechanical test in rats. 144 growing male rats were used, 23 days old, and 36.7 ± 0.6 grams of body weight were divided into 04 experimental groups (n = 36) and kept in individual cages during the experimental period of 56 days: Group Control (GC); Mos Group 1 (GM1); Mos Group 2 (GM2); and Group 3 Mos (GM3). Densitometric analysis and biomechanical testing of bone mineral content were conducted in four stages: 14, 28, 42 and 56 days after beginning the experiment. Simple linear regressions were adjusted data pairs situation, time of collection (every 14 days) and results of bone mineral content parameters (BMC), bone mineral density (BMD), area (A), energy, maximum strength and stiffness. The regressions set of treatments for each parameter were compared in pairs by the intercept and slope of the straight and revealed significant differences between treatments (P <0.0125) in the area parameters, energy absorbed to the maximum strength and maximum strength. The slope of the lines was higher in groups supplemented with MOS compared to the CG. MOS intake increased bone mineralization, which, in turn, increased the resistance to fracture of the femur in all the biomechanical properties and densitometric studied, perhaps due to an increase in the intestinal absorption of nutrients in rats. Given the beneficial results of this study with growing rats as experimental model, it is suggested that this functional food can be used as a food component enhancing bone health.