Prebióticos melhoram os indicadores de osteoporose em modelo pré-clínico: revisão sistemática com meta-análise

Abstract

Introduction: Osteoporosis is a metabolic disease of bone tissue, characterized by the gradual loss of bone mass and the microarchitectural deterioration of bone tissue in men, resulting in bone fragility and a risk of fractures. Bone impairment leads to an increase in the cost of health services with medical consultations, hospitalizations and hopices related to osteoporotic fractures, being a serious public health problem. Objective: This systematic review with meta-analysis aimed to elucidate the effects of prebiotics on induced osteoporosis in ovariectomized rats. Material and methods: The data and methods used in the statistical analysis were obtained through searches in the scientific databases available on the Internet: "Pub Med", "ScienceDirect", "SciELO", "LILACS", "Cochrane" and "bireme "2018 before. found 813 complete articles, abstracts or book chapters that cited the key words in the bibliographic research, after screening of titles and abstracts, six studies met the inclusion criteria, in total 116 animals were used, divided randomly between control groups and treatment. The following experimental works were selected: (i) Population: murine (rats / mice) ovariectomized; (ii) Intervention: dietary supplementation with prebiotics; (iii) Control: dosage of supplements and not supplemented; (iv) Outcomes: evaluation of osteoporosis indicators. We used the Risk Analysis software 5 to measure the meta-analysis calculations and bias risk assessment. Results: Bone mineral density (BMD), bone mineral content (BMD) and bone biomechanical data from the six included studies demonstrated that serum levels are able to register from them. Conclusion: This meta-analysis provided evidence that prebiotic activity is involved in anti-osteoporotic mechanisms and suggests that further studies in humans should be performed using prebiotics as a therapeutic alternative or therapy complementary to conventional postmenopausal osteoporosis treatments in humans.