Associação entre Staphylococcus aureus e parâmetros laboratoriais de pacientes com rinossinusite crônica com polipose nasossinusal

Abstract

Background: Chronic rhinosinusitis with Nasosinusal Polyps (CRSwP) is an inflammatory disease of the paranasal sinuses and nasal cavities that may be related to the presence of the bacterium of the genus Staphylococcus. Methodology: We selected 50 patients with CRSwP and socio-epidemiological information, nasal and oropharyngeal bacterial samples were collected. Isolated S. aureus samples were submitted to the antimicrobial susceptibility test. The classic staphylococcal enterotoxin and biofilm genes were determined. Total immunoglobulins as well as leukogram were measured. Results: 35 S. aureus samples were identified from the 27 patients colonized by this bacterium, all of them with capacity to produce biofilm. Multiple antimicrobial resistances were detected in 74.3% of the isolates. An association between bacterial carrier, immunoglobulin levels and leukocyte count was verified, observing an increase in the levels of monocytes and lymphocytes with the presence of S. aureus. Levels of IgE and the presence of the sec-1 gene were correlated. Conclusion: There was a carrying of multiresistant S. aureus with potential for biofilm formation and a negative association between the enterotoxin C gene and IgE production, suggesting that this enterotoxin may be associated with no formation of nasal polyps in some pacients.