Análise dos efeitos do consumo de cúrcuma e de simbiótico em ossos de ratos submetidos ao uso de glicocorticoide

Abstract

Glucocorticoids have adverse side effects that can trigger osteoporosis. There is evidence showing that symbiotics and curcumin can prevent bone loss. The objective of the work was to analyze possible effects of curcumin and symbiotic on the bones of female rats submitted to osteoporosis induction by dexamethasone for 5 weeks. 50 Wistard rats were used, distributed in five groups: control group (CT), control osteoporosis group (OC), osteoporosis and symbiotic group (OS), osteoporosis and curcumin group (OCCM) and osteoporosis and symbiotic / curcumin group (OSC). Dexamethasone was applied three times a week, while symbiotic and curcumin were administered daily. After euthanizing the animals, measurements of alkaline phosphatase and calcium were performed, analysis of structural and material properties and Raman analysis of the femurs. Alkaline phosphatase was higher in the OCCM group. The maximum strength and structural stiffness were higher in the CT group. The tension was lower and similar between the osteoporosis groups. The CT group had a lower percentage of relative deformation, the OC group had a greater deformation compared to the OCCM groups and the OS group was more deformed than the OCMM group. The CT group presented a greater elastic modulus in relation to the OC, OS and OSC groups. The 960/1660 ratio of the OC, OS and OSC groups were different from the CT group. The 1070/1660 ratio was higher in the OCCM group. So, it was possible to verify that curcumin has promising effects related to the increase in bone strength and mineralization through the induction of osteoporosis by glucocorticoid.