Resposta sorológica e clínica às vacinas Pneumo-10 e Pneumo-23 em um hospital público

Abstract

Background: Pneumococcal disease is one of the leading causes of death worldwide. Objective: To determine the epidemiology, serological and clinical response to PPV23 in children under 12 years of age who had recurrent airway infections, previously vaccinated with PMN10, followed at the immunodeficiency clinic of the Hospital Regional of Presidente Prudente-SP (HR). Materials: Medical records were analyzed; dosages of antibodies to PNM10 and to PPV23 were obtained before and after the application of the vaccine. Epidemiological aspects, comorbidities, immunological alterations were determined and the clinical improvement of patients after vaccination was evaluated. Results: There was an increase in antibody levels against different PPV23 serotypes after vaccination, as well as clinical improvement in 76% of patients, with a reduction in infectious processes, reduction in the use of antibiotics, and in emergency room visits. Conclusion: In the population studied, vaccination with PPV23 provided the improvement of patients and may represent savings for the SUS. The model can be applied to different services with poor resource settings, even without having a specialized outpatient clinic.