Administração de resveratrol melhora parâmetros comportamentais semelhantes ao transtorno do espectro do autismo induzido em modelo animal: revisão sistemática com meta-análise

Abstract

Autism spectrum disorders (ASD) are a diverse group of conditions. They are characterized by some degree of difficulty with social interaction and communication and may be more vulnerable to developing chronic non-communicable conditions due to behavioral risk factors such as physical inactivity and poor food preferences, and are at increased risk of violence, injury and abuse. Health insurance covers some of these expenses, but families of autistic children have high out-of-pocket costs. ASD-like disorders are induced by propionic or valproic acids in an animal model, rats and mice, in the pre- and postnatal phases. The phenolic resveratrol (RSV) has demonstrated the ability to beneficially influence behavioral parameters similar to ASD, sociability, social preference for novelty, self-cleaning/self-care and reciprocal social interaction, but the results are controversial and scarce in animal and human models. The objective of this systematic review with meta-analysis was to compile the results of the included studies and analyze the effects of resveratrol on behavioral indicators similar to ASD in an animal model, rats and mice. The searches were carried out in the databases: “PubMed”, “ScienceDirect”, “Web of Science”, “Scielo” and Google in April 2021, and repeated in December 2021, using the keywords “resveratrol”,” autism spectrum disorder”, “autistic disorder”, “rats” and “mice”. 4 eligible articles were included in the meta-analyses. The results obtained demonstrate beneficial effects (P<0.05) of RSV associated with time spent on behavioral parameters: sociability actions, preference for social novelty, reciprocal social interaction and self-cleaning/self-care. Our results demonstrate that RSV phenolic activity improves behavioral parameters, sociability actions, preference for social novelty, reciprocal social interaction and self-grooming/self-care in rats and mice with ASD-like characteristics and induced by propionic or valproic acids.