Ação da N-acetilcisteína associada ao treinamento concorrente em parâmetros reprodutivos de ratos espontaneamente hipertensos

Abstract

High blood pressure leads to oxidative stress that is harmful to different cell types, being an important risk factor for human health. One of the systems that suffer these undesirable effects of hypertension is the reproductive system. Physical exercise improves hypertension and the body's general health and n-acetylcysteine (NAC) has an anti-oxidative effect on cells. This study was divided into two Chapters: Chapter I is a literature review on the topic and Chapter II is an experimental study in the format of a scientific article that describes the experiment carried out to verify the action of n-acetylcysteine (NAC) associated to concurrent training on angiogenesis and oxidative stress in testicles of spontaneously hypertensive rats (SHR). It was carried out using 48 SHR rats that were divided into 4 groups with 12 animals: Control sedentary group (S); Concurrent training group (TC), SHR submitted to the concurrent training protocol combining aerobic exercise on a treadmill with resistance exercise (four climbs up the stairs with loads), three times a week, on alternate days, for a period of eight weeks; NAC sedentary Group (SNAC), SHR who received NAC at a dose of 120mg/kg/day orally for eight weeks; and NAC Group + Concurrent Training (TNAC). The animals' testicles were used for: testicular and sperm morphology; the expression of mediators related to angiogenesis, oxidative stress and apoptosis; and the oxidative profile. Physical exercise improves hypertension and the body's general health and n-acetylcysteine (NAC) has an antioxidant effect on cells. The objective of the research was to verify the action of NAC associated with concurrent training on angiogenesis and testicular oxidative stress in spontaneously hypertensive rats (SHR).