Eficácia clínica da pregabalina em cadelas submetidas à mastectomia unilateral radical e ovariosalpingohisterectomia

Abstract

The objective was to evaluate the analgesic efficacy of pregabalin as an adjuvant in the control of postoperative pain in bitches submitted to mastectomy. Twenty-four bitches were evaluated, referred for unilateral radical mastectomy and ovariosalpingohysterectomy, which were divided into two groups of twelve animals each: GP: administration of pregabalin 4mg/kg orally (VO); GC: VO administration of placebo solution. In all animals, pre-anesthetic medication was administered with morphine (0.3 mg/kg) intramuscularly (IM). Fifteen minutes later, cephalic vein catheterization was performed. Anesthetic induction and maintenance were performed with propofol (4 mg/kg, IV) and isofluorane, respectively. Meloxicam (0.2 mg/kg, IV) was administered five minutes before the surgical incision. In the postoperative period, the degree of analgesia was measured at 0.5, 1, 2, 4, 8, 12 and 24 hours after tracheal extubation using the Iteractive and Dynamic Visual Analog Scale (DIVAS) and the Modified Glasgow Composite Scale - Form Abbreviated (CMPS-SF). At the same times, the degree of sedation was also evaluated using the Sedation Scale for Dogs. Rescue analgesia was performed with morphine (0.5 mg/kg IM) in cases of pain score equal to or greater than 6 on the CMPS-SF. The data were submitted to the Shapiro-Wilk normality test to identify their distribution; the scores obtained from the evaluation of the degree of analgesia and sedation were evaluated by the Mann-Whitney test. Friedman's test was used to evaluate the treatment during the same group. Fisher's exact test was used to compare the number of dogs that received supplemental analgesia. It was concluded that the administration of pregabalin did not reduce the analgesic rescue requirement for pain control in the postoperative period of dogs after mastectomy and ovariosalpingohysterectomy.