Influência positiva da combinação de biocurativo e fibrina rica em plaquetas autóloga na cicatrização de feridas dérmicas induzidas em coelhos

Abstract

Technological advances have led to the development of a wide variety of dressings intended for different types of wounds, aiming to address the four phases of healing. The ideal dressing should promote rapid healing, preserve skin hydration, be oxygen-permeable, non-adherent, hypoallergenic, and provide an effective barrier against contaminants, all at an affordable cost and with minimal discomfort to the patient. Biopolymers, such as chitosan, are widely used in wound treatment due to their biocompatibility, biodegradability, and similarity to macromolecules recognized by the body. However, many biopolymer-based formulations still face challenges. Thus, the combination of these materials with biomaterials such as Platelet-Rich Fibrin (PRF) is seen as a promising strategy for the future of wound healing. The present study aimed to characterize the histomorphometric effects of using biomaterials, with or without the bioactive dressing of chitosan complexed with xanthan and β-glucan, on the healing of experimentally induced wounds in rabbits. To that end, skin biopsies from 24 rabbits were evaluated on days 7, 14, 21, and 28 of the experiment. The results showed that aPRF significantly reduced the incidence of necrosis. On the other hand, when this biomaterial was associated with the dressing, a lower incidence of hemorrhage and a greater amount of inflammatory infiltrate were observed throughout the experimental period. It can be concluded that both the biodressing and PRF exhibit their best effects when used separately and at different times.